The levels of certain circulating microRNAs in hypertrophic cardiomyopathy are associated with echocardiographic parameters

Background. Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease; it characterized by left ventricular (LV) hypertrophy that cannot be explained hemodynamic causes. It believed sarcomere dysfunction underlies pathogenesis of this disease, however, only half patients with HCM phenotype have mutations in sarcomere-encoding genes. distinguished both high genetic and clinical heterogeneity therefore more studies are seeking to investigate a regulation gene expression how abnormalities process can affect disease phenotype. One levels post-transcriptional level mediated short non-coding microRNAs inhibit protein synthesis.
 Aim. To identify correlations between circulating microRNAs, previously shown associated HCM, parameters patients.
 Materials methods. Correlation analysis miR-499a-5p, miR-454 miR-339-5p plasma 33 patients, examined from 2019 2021, has been performed.
 Results. Variants HCM-associated genes were found 49% patients. There no differences genotype-positive genotype-negative MiR-499a-5p correlated LV ejection fraction, diastolic function atrium dimension.
 Conclusion. Levels certain correlate echocardiographic